T cell receptor beta variable 13 (TRBV13)

T cell receptor beta variable 13 (TRBV13) is a protein-coding gene encoding the V (variable) region of the beta chain of the alpha-beta T cell receptor, which participates in antigen recognition on T lymphocytes[1][5]. Alpha-beta T cell receptors recognize peptide-major histocompatibility (pMH) complexes presented by antigen-presenting cells, initiating signal transduction events critical for adaptive immunity. This triggers downstream intracellular pathways—including calcium signaling, MAPK, and NF-κB pathways—that regulate gene expression, T cell growth, and differentiation[1]. The TCR repertoire, including TRBV13, is generated through V-(D)-J recombination in the thymus and is essential for recognizing diverse antigens as part of the adaptive immune response[1][5]. **Notes on additional fields:** - No specific interacting drugs, biomarkers, safety concerns, or therapeutic mechanisms were found in the provided or standard reference sources. - This target is not usually a direct therapeutic target (e.g., not bound by therapeutic drugs), but as a T cell receptor component, it is highly relevant for immunological research and T cell monitoring. - TRBV13 is specific to the variable domain of T cell receptor beta chains, a crucial molecular determinant for antigen specificity in T cell–mediated immunity[1].

Other names

TCRBV13S1TCRBV23S1A2TV segment translation productTRBV13