T cell receptor beta variable 23-1 (non-functional) (TRBV23-1)

T cell receptor beta variable 23-1 (non-functional) is a predicted non-functional open reading frame (pseudogene) within the variable (V) region of the T cell receptor beta chain. While alpha-beta T cell receptors (TCRs) are essential for adaptive immunity and antigen recognition, TRBV23-1 does not typically contribute to productive TCR chains due to altered recombination sites or amino acid changes that impair function. Unlike functional TRBV genes, TRBV23-1 rarely participates in the generation of antigen-specific T cell responses. Expression has been detected at mRNA and, in some studies, protein level, but the resulting product is generally non-functional and lacks the ability to undergo normal V-(D)-J recombination or form productive receptor complexes capable of cell signaling.

Other names

Probable non-functional T cell receptor beta variable 23-1TRBV23-1TRBV231TCRBV19S1PTCRBV23S1T cell receptor beta variable 23-1 pseudogene

None, as there are no drugs targeting TRBV23-1 and it does not produce a functional receptor protein