T cell receptor beta variable 6-7 (non-functional) (TRBV6-7)

The **T cell receptor beta variable 6-7 (non-functional)** (TRBV6-7) is a pseudogene encoding a probable non-functional open reading frame for the V region of the variable domain of the T cell receptor beta chain[1]. It resides in the TCR beta locus on chromosome 7q34, which includes genes involved in the diversity of T cell receptor beta chain variable regions and their rearrangement[4]. This particular gene variant has been reported to be non-functional, meaning it is not used in productive TCR beta chain synthesis due to alterations at the nucleotide or protein level such as recombination defects or essential amino acid substitutions, leading to a lack of a functional protein product[1]. While functional TCR beta variable genes contribute essentially to immune recognition by T cells, TRBV6-7 itself does not encode a protein with such function, and there are no known drugs, mechanisms, or biomarker uses associated with this gene segment. Certain polymorphisms in TCR beta variable regions, including those at or near TRBV6-7, have been studied for their association with autoimmune conditions and population genetics but not as direct therapeutic targets[2][1].

Other names

TCRBV13S8PTCRBV6S7TRBV67T-cell receptor TRB locus TRBV6-7*01T-cell receptor TRB locus TRBV6-7*01_S4559T-cell receptor TRB locus TRBV6-7*01_S7249TCR beta chain Vbeta13S8P-GSTLEQFF-Jbeta2.1