Target intelligence / Profile preview

T-cell Receptor Delta Chain V Region 2 (TRDV2)

Target: TRDV2
Molecular classification: Receptor, T cell receptor subunit, Immunoglobulin-like domain protein

Overview

The T-cell receptor delta chain V region 2 (TRDV2) is a variable region gene segment of the T cell receptor (TCR) delta chain in humans. It is a key component of the γδ T cell receptor, responsible for antigen recognition. TRDV2-expressing γδ T cells play a role in immune surveillance against infections and tumors by recognizing stress-induced ligands independently of classical MHC presentation. Upon ligand binding, the γδTCR/CD3 complex initiates intracellular signaling, leading to cytokine secretion, proliferation, and cytotoxicity.

Mechanism of action

N/A

Biological functions

Antigen recognitionImmune responseT cell signaling

Disease associations

InfectionCancerAutoimmunity

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