T cell receptor delta joining 4 (TRDJ4)

T cell receptor delta joining 4 (TRDJ4) is a *joining (J) gene segment* of the T cell receptor delta (TRD) locus in humans. It encodes a short stretch of amino acids that, through V(D)J recombination, contributes to the hypervariable region (CDR3) of the T cell receptor delta chain. This region is essential for antigen recognition diversity by γδ T cells. TRDJ4 itself is not transcribed or translated as a stand-alone product; it forms part of the mature TCR delta chain only following rearrangement with variable (V) and diversity (D) segments during T-cell development in the thymus[1][3][5]. As a small recombination segment, it is not considered a drug target or disease gene, but is crucial for generating the antigen receptor repertoire required for immune recognition. If you are interested in T cell receptor delta (TRD) chain as a potential therapeutic target, the correct entity would be "T cell receptor delta chain" or "T cell receptor (gamma/delta)" rather than an individual joining segment like TRDJ4.

Other names

T cell receptor delta joining segment 4TRDJ4 (self-abbreviation and locus name)