T-cell receptor on cytomegalovirus pp65-specific T cell (TCR (for antigen-specific TCRs, no unique abbreviation for pp65-specific TCRs is in wide use))

The T-cell receptor on cytomegalovirus pp65-specific T cells is a membrane-bound heterodimeric protein (typically αβ TCR) that recognizes peptides derived from the HCMV pp65 tegument protein presented on HLA molecules. These TCRs are central to the cellular immune response against HCMV, especially in immunocompromised settings such as after hematopoietic stem cell transplantation. The pp65-specific T-cell response is highly polyfunctional, involving both cytotoxicity and cytokine production, and serves as a key target for immunotherapies including TCR-engineered T-cell therapies to treat or prevent CMV infection. The diversity and sharing of pp65-specific TCR clonotypes between individuals support their importance in immune protection, with clinical interest for both disease monitoring and therapeutic interventions[1][4][5][6][9]. If you require more granular information (e.g., exact peptide specificity or HLA restriction), further narrowing may be needed since “T-cell receptor on pp65-specific T cells” encompasses a diversity of TCRs with distinct peptide/MHC binding specificities[1][3][4][9].

Other names

CMV pp65-specific T-cell receptorHCMV pp65-specific TCRTCR recognizing pp65pp65-specific TCR

Antigen-specific T-cell activation; Cytolytic activity upon recognition of CMV-infected cells; Cytokine release (e.g., IFN-γ, TNF-α, IL-2)