T cell receptor on HPV16-specific cytotoxic T lymphocyte (TCR)

The T cell receptor (TCR) on HPV16-specific CD8+ T cells is a highly variable, heterodimeric membrane receptor (composed of α and β chains), specialized for recognizing short peptide fragments derived from the human papillomavirus type 16 (HPV16) presented on major histocompatibility complex class I (MHC-I) molecules. This receptor, in combination with the CD8 co-receptor, mediates antigen-specific activation of cytotoxic T lymphocytes, triggering targeted killing of HPV16-infected or malignant cells. Recognition depends on both the unique peptide specificity encoded in the TCR variable regions and the restriction by the presenting MHC allele. Such TCRs are critical for immune control of HPV16 infections and associated malignancies. In therapeutic contexts, genetically engineered TCRs targeting HPV16 antigens have been used in adoptive cell therapies for cancer treatment.

Other names

TCR on HPV16-specific CD8+ T cellHPV16-specific TCRHuman papillomavirus 16-specific T cell receptor

Recognition of HPV16-derived peptide presented on MHC class I, leading to CD8+ T cell activation, proliferation, and specific cytolytic response toward infected or malignant cells expressing HPV16 antigens.