T cell receptor recognizing Acer saccharinum pollen-derived peptides (TCR)

T cell receptors (TCRs) recognizing Acer saccharinum (Silver Maple) pollen-derived peptides are specialized surface receptors on T lymphocytes that mediate the cellular immune response to silver maple allergens. These TCRs identify specific epitopes, such as those from the pectate lyase allergen Ace s 1, presented by Major Histocompatibility Complex (MHC) molecules on antigen-presenting cells (IUIS Allergen Nomenclature). In sensitized individuals, the engagement of these TCRs triggers a Th2-biased inflammatory cascade, leading to the production of allergen-specific IgE and the clinical manifestations of allergic rhinitis and seasonal asthma (AAAAI). Therapeutic strategies targeting these TCR-mediated pathways primarily involve allergen-specific immunotherapy (AIT), which aims to desensitize the immune system through repeated, controlled exposure to the allergen. This process induces a shift from a Th2-dominated response to a regulatory T cell (Treg) or Th1-dominated response, effectively promoting long-term immune tolerance and reducing symptom severity (Akdis & Akdis, 2014). Understanding the TCR repertoire and specific peptide-MHC interactions is essential for the development of next-generation peptide-based vaccines and precision diagnostics for tree pollen allergies.

Other names

Silver maple allergen-specific T-cell receptorAcer saccharinum-specific TCRT-cell receptor for Ace s allergens

Induction of peripheral T-cell tolerance through mechanisms such as anergy, clonal deletion, and the generation of regulatory T cells (Tregs) that suppress Th2-mediated allergic inflammation (Akdis & Akdis, 2014).