T cell receptor recognizing Alnus rhombifolia-derived peptide–MHC complexes (Aln r 1-TCR)

The T cell receptor (TCR) recognizing Alnus rhombifolia-derived peptide–MHC complexes is a specialized immune receptor found on the surface of T lymphocytes that specifically binds to peptides derived from the major white alder pollen allergen, Aln r 1, when presented by Major Histocompatibility Complex (MHC) molecules, typically HLA-DRB1*01:01. This recognition event is a critical step in the pathogenesis of allergic rhinitis and asthma in individuals sensitized to alder pollen, as it triggers the activation of Th2-polarized T cells and the subsequent release of pro-inflammatory cytokines. In the context of disease, these TCRs mediate the hypersensitivity response to inhaled pollen, leading to chronic airway inflammation. Therapeutic strategies targeting this interaction include allergen-specific immunotherapy (AIT), which aims to induce immunological tolerance by modulating TCR signaling or promoting the expansion of regulatory T cells. Understanding the structural basis of this TCR-pMHC interaction is essential for the development of next-generation vaccines and peptide-based therapies designed to desensitize allergic patients.

Other names

Aln r 1-specific T cell receptorWhite alder allergen-specific TCRTCR recognizing Aln r 1:HLA-DRB1*01:01