T-cell receptor recognizing CRM197-derived peptide–MHC class II complex (TCR-CRM197-pMHCII)

T-cell receptors (TCRs) recognizing CRM197-derived peptide–MHC class II complexes are specialized immune receptors that mediate the recognition of the cross-reacting material 197 (CRM197) protein [1]. CRM197 is a genetically detoxified version of the diphtheria toxin, widely utilized as a carrier protein in conjugate vaccines to enhance the immunogenicity of polysaccharide antigens [2]. These TCRs, located on the surface of CD4+ T helper cells, bind to specific CRM197 peptides presented by Major Histocompatibility Complex (MHC) class II molecules on antigen-presenting cells [3]. This binding event is the fundamental step in providing T-cell help to B cells, which is necessary for isotype switching and the development of high-affinity antibodies against the vaccine's target pathogen [1]. Consequently, these TCRs play a pivotal role in the efficacy of vaccines protecting against diseases such as pneumonia, meningitis, and Hib [2]. Research into these receptors helps in understanding individual variations in vaccine response and the potential for carrier-induced epitopic suppression [3]. Understanding the repertoire and specificity of these TCRs is vital for optimizing vaccine immunogenicity and addressing variations in population-wide immune responses [1][2].

Other names

CRM197-specific T-cell receptorT-cell receptor recognizing cross-reacting material 197 peptide-MHC IIDiphtheria toxin mutant-specific TCRCRM197-pMHCII-specific TCR

Recognition of CRM197-derived peptides presented on MHC class II molecules by CD4+ T cells, leading to T-cell activation and subsequent cytokine secretion that facilitates B-cell maturation and antibody production against conjugated antigens [1][2].