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Target intelligence / Profile preview
T cell receptor recognizing Folate Receptor alpha-derived peptide–MHC complexes (FRα-specific TCR)
- Target
- FRα-specific TCR
- Molecular classification
- T cell receptor, Antigen-specific receptor, Heterodimeric glycoprotein
01
Overview
- Other names
- Folate receptor alpha-specific T-cell receptorFOLR1-specific TCRFRalpha-TCRTCR recognizing FRα 191-199E39-specific T-cell receptorFBP-specific TCR
02
Mechanism of action
Recognition of specific FRα-derived peptides (e.g., E39/FRα 191-199) presented by MHC Class I molecules (typically HLA-A*02:01), leading to T-cell activation, cytokine release (IFN-gamma, IL-2), and targeted lysis of FRα-expressing tumor cells.
03
Biological functions
Antigen recognitionImmune responseT cell activationCytotoxicitySignal transduction
04
Disease associations
Ovarian cancerNon-small cell lung cancerTriple-negative breast cancerEndometrial cancerRenal cell carcinoma
05
Safety considerations
On-target off-tumor toxicity (kidney, lung, choroid plexus)Cytokine Release Syndrome (CRS)NeurotoxicityAntigen escape/downregulationMHC downregulation by tumors
06
Interacting drugs
ITIL-306
2 more in the full profile.
07
Biomarkers
FOLR1 expressionHLA-A*02:01 genotypeFRα 191-199 peptide presentationSerum FRα levels
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