T-cell receptor recognizing human telomerase reverse transcriptase peptide-MHC complex (TCR (hTERT peptide-MHC complex))

The T-cell receptor recognizing hTERT peptide-MHC complex is a specialized immune receptor on T cells engineered or selected to bind the cancer-associated antigen hTERT when presented by MHC class II molecules such as HLA-DP04 and HLA-DP03. This targeted recognition leads to immune activation and offers a promising strategy for adoptive cell therapy in solid cancers, leveraging the universality of hTERT expression in malignancies. The receptor underlies the mechanism by which engineered T cells (e.g., Radium-4 TCR) can specifically attack tumor cells and activate broad anti-tumor immunity.

Other names

TCR targeting hTERThTERT-specific TCRRadium-4 TCR

Recognition of hTERT-derived peptide presented by MHC class II on antigen-presenting cells or tumor cells leads to T cell activation, cytokine release, and killing of hTERT-expressing cancer cells