T-cell receptor recognizing Malassezia globosa allergen 1 (Mala g 1) peptide 56–70–MHC class II complex (TCR-Mala g 1 (56-70)-MHC II)

The T-cell receptor (TCR) on allergen-specific CD4+ T cells recognizing the MG56 peptide–MHC class II complex is a critical molecular mediator in the pathogenesis of atopic dermatitis (AD) associated with Malassezia globosa sensitization. MG56 refers to an immunodominant epitope derived from the Mala g 1 allergen, specifically the peptide sequence spanning residues 56 to 70, which is presented by MHC class II molecules such as HLA-DRB1*04:05. Recognition of this complex by the TCR triggers the activation and clonal expansion of Th2-polarized CD4+ T cells, which secrete pro-inflammatory cytokines like IL-4 and IL-13. These cytokines drive the production of allergen-specific IgE and promote eosinophilic infiltration, contributing to the chronic inflammation and skin barrier dysfunction characteristic of AD. Research has shown that these specific TCRs often exhibit restricted Vβ usage, particularly Vβ13.1, making them potential targets for highly specific immunomodulatory interventions. Therapeutic strategies targeting this interaction include allergen-specific immunotherapy (AIT) and experimental peptide-based vaccines designed to induce immune tolerance or shift the T-cell response toward a regulatory profile.

Other names

Mala g 1-specific T-cell receptorMG56-specific T-cell receptorMalassezia globosa-specific TCRTCR recognizing MG56-MHC II

Desensitization and induction of immune tolerance through T-cell anergy, deletion, or the promotion of regulatory T-cell (Treg) differentiation to suppress Th2-mediated allergic inflammation.