T-cell receptor recognizing ovalbumin peptide–major histocompatibility complex (TCR (OVA-specific), OT-I TCR or DO11.10 TCR (if specifying canonical mouse models))

A T-cell receptor recognizing OVA-peptide/MHC complex is a heterodimeric cell surface receptor expressed on T-lymphocytes that binds with high specificity to a defined peptide epitope derived from ovalbumin, presented on the surface of cells by a major histocompatibility complex (MHC; either class I or II, depending on peptide and system)[3][7][2][1][6]. Binding of this pMHC ligand induces intracellular signaling and T-cell activation, making this system a classical model in immunology for dissecting antigen-specific T-cell responses, affinity/kinetics, tolerance, and cross-reactivity[3][7][4][2]. The most studied forms are the OT-I TCR (CD8+, SIINFEKL/H-2K^b^, MHC I) and DO11.10 TCR (CD4+, OVA 323–339/I-A^d^, MHC II), which provide powerful tools for adoptive T-cell transfer, vaccination, and basic immunological research in mice[2][6][1]. This is not a single universal receptor, but a functional description of TCRs specific for OVA-derived peptide/MHC complexes. If you require information on a specific TCR clone, such as OT-I (class I) vs. DO11.10 (class II), more details can be provided for that exact target.

Other names

OVA-specific T-cell receptorOT-I TCR (class I, SIINFEKL/H-2K^b^)DO11.10 TCR (class II, OVA 323–339/I-A^d^)TCR-pMHC OVA complexOVA-reactive TCR

Recognition of antigenic OVA peptide in the context of MHC leading to T-cell activation - Downstream signaling through CD3 complex upon pMHC binding