T cell receptor recognizing Quercus agrifolia pollen-derived peptides (TCR-Que-a)

T cell receptors (TCRs) recognizing Quercus agrifolia (Coast live oak) pollen-derived peptides are specialized protein complexes found on the surface of T lymphocytes that mediate the immune system's response to oak pollen allergens. These receptors specifically bind to allergenic peptides, such as those derived from the major allergen Que a 1, when they are presented by Major Histocompatibility Complex (MHC) molecules on antigen-presenting cells. In sensitized individuals, this recognition triggers a Th2-biased immune response, leading to the production of IgE antibodies and the subsequent release of inflammatory mediators responsible for allergic rhinitis and asthma. These TCRs are primary targets for allergen-specific immunotherapy, which aims to desensitize the patient by modulating TCR signaling and inducing immune tolerance. Understanding the specific TCR-peptide-MHC interaction is crucial for developing precision vaccines and monitoring the efficacy of treatments for oak pollen allergies.

Other names

Coast live oak pollen-specific T cell receptorQuercus agrifolia allergen-specific TCROak pollen-reactive T cell receptorQue a 1-specific T cell receptor

Allergen immunotherapy works by inducing peripheral T cell tolerance, shifting the immune response from a Th2-dominated profile to a Th1 or Treg profile, and promoting the production of IgG4 blocking antibodies. Pharmacological agents like corticosteroids or calcineurin inhibitors non-specifically suppress the TCR-mediated signaling cascade to reduce inflammation.