T-cell receptor restricted by HLA-A*24:02 (HLA-A*24:02-restricted TCR)

The HLA-A*24:02-restricted cytotoxic T lymphocyte receptor (TCR) is a heterodimeric protein complex on the surface of CD8+ T cells that specifically recognizes peptide antigens presented by the HLA-A*24:02 allele of the Major Histocompatibility Complex (MHC) Class I [1, 3]. This recognition is a cornerstone of the cellular immune response, enabling T cells to detect and destroy cells presenting non-self or mutated peptides, such as those from viruses or tumors [3]. HLA-A*24:02 is highly prevalent in East Asian populations, particularly in Japan, where it is found in approximately 60% of the population, making it a primary focus for the development of TCR-engineered T-cell (TCR-T) therapies [1, 4]. In these applications, T cells are modified to express a TCR that targets specific antigens like WT1, NY-ESO-1, or MAGE-A4 when presented by HLA-A*24:02 [2, 4]. Binding of the TCR to the peptide-HLA complex triggers a signaling cascade that leads to the release of cytotoxic granules, such as perforin and granzymes, resulting in the apoptosis of the target cell [3].

Other names

HLA-A*24:02-restricted TCRA24-restricted TCRHLA-A24-restricted T-cell receptorHLA-A*24:02-restricted cytotoxic T lymphocyte receptor

TCR-engineered T cells express this receptor to recognize and bind specific peptide-HLA-A*24:02 complexes on target cells, inducing T-cell activation and cytotoxic effector functions.