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T cell receptor Vgamma9Vdelta2

Molecular classification: Receptor, Heterodimeric protein complex

Overview

The T cell receptor (TCR) Vγ9Vδ2 is a specific heterodimeric receptor found on a major subset of human gamma delta (γδ) T cells. These cells recognize non-peptide phosphoantigens in an MHC-independent manner, playing roles in antimicrobial defense and tumor surveillance. Activation leads to cytotoxicity, cytokine production, and immunoregulation, making them attractive targets for immunotherapy.

Other names: Vγ9Vδ2 TCRVgamma9Vdelta2 TCR

Mechanism of action

Agonism via phosphoantigen binding and co-receptor engagement, leading to T cell activation and cytotoxicity.

Biological functions

Immune responseCytotoxicityCytokine productionImmunoregulationAntigen recognition

Disease associations

CancerInfectionTuberculosisViral infections

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