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Target intelligence / Profile preview
T Cell Surface Antigen (TCSA)
- Target
- TCSA
- Molecular classification
- Receptor, Cell Surface Protein, Co-receptor, Immunoglobulin superfamily
01
Overview
T cell surface antigens are molecules expressed on the surface of T lymphocytes, crucial for adaptive immunity. The T cell receptor (TCR) recognizes peptide-MHC complexes, initiating T cell activation and downstream effector functions. Other key surface molecules, such as CD4 and CD8, serve as co-receptors. These antigens play critical roles in immune surveillance and can be targeted therapeutically in various diseases, including cancer and autoimmune disorders.
- Other names
- T cell receptorTCRCD4CD8CD28CD69CD71CD25HLA-DRCTLA-4
02
Mechanism of action
Varies depending on the specific antigen/receptor and drug; includes receptor agonism/antagonism, immune checkpoint blockade, targeted cell killing, and immunosuppression.
03
Biological functions
Antigen recognitionT cell activationImmune responseSignal transductionT cell differentiationT cell proliferation
04
Disease associations
CancerAutoimmune diseasesInfectious diseasesImmunodeficiencyInflammation
05
Safety considerations
Cytokine release syndrome (CRS)Immune-related adverse events (irAEs)Graft-versus-host disease (GvHD)Opportunistic infectionsAutoimmunity
06
Interacting drugs
CAR-T cell therapy
3 more in the full profile.
07
Biomarkers
TCR clonalityCD4/CD8 ratioExpression levels of activation markers (e.g., CD69, CD25, HLA-DR)Cytokine production (e.g., IFN-γ, IL-2)
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