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Target intelligence / Profile preview
T-cell Surface Antigen CD2 (CD2)
- Target
- CD2
- Molecular classification
- Cell surface glycoprotein, Immunoglobulin superfamily
01
Overview
CD2 is a cell surface glycoprotein primarily expressed on T cells and NK cells. It functions as an adhesion and co-stimulatory molecule, playing a critical role in T-cell activation, immunological synapse formation, and immune responses. It interacts with LFA-3 (CD58) and is involved in downstream signaling pathways through association with kinases like Lck and Fyn. CD2 is used as a diagnostic marker for T cells and NK cells and is implicated in various diseases, including lymphomas, leukemias, and immune disorders. Anti-CD2 monoclonal antibodies have been explored as therapeutic agents to modulate immune responses.
- Other names
- T11/Leu-5LFA-2LFA-3 receptorErythrocyte receptorRosette receptor
02
Mechanism of action
Modulation of immune responses (e.g., reducing overactive responses or inducing hyporesponsiveness)
03
Biological functions
Cell-cell adhesionCo-stimulationT-cell receptor (TCR) signaling modulationImmune cell activation
04
Disease associations
LymphomaLeukemiaImmune disordersViral evasion
05
Safety considerations
Potential for modulating immune responses (inducing hypo- or hyper-responsiveness)Pathogen evasion strategies targeting CD2/LFA-3 interaction
06
Interacting drugs
Anti-CD2 monoclonal antibodies
07
Biomarkers
Expression on T cells and NK cells (diagnostic marker)Pan-T phenotype in lymphomas/leukemias
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