Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
T-cell Surface Antigen CD2 (CD2)
- Target
- CD2
- Molecular classification
- Cell surface glycoprotein, Immunoglobulin superfamily
01
Overview
CD2 is a cell surface glycoprotein primarily expressed on T cells and NK cells. It functions as an adhesion and co-stimulatory molecule, playing a critical role in T-cell activation, immunological synapse formation, and immune responses. It interacts with LFA-3 (CD58) and is involved in downstream signaling pathways through association with kinases like Lck and Fyn. CD2 is used as a diagnostic marker for T cells and NK cells and is implicated in various diseases, including lymphomas, leukemias, and immune disorders. Anti-CD2 monoclonal antibodies have been explored as therapeutic agents to modulate immune responses.
- Other names
- T11/Leu-5LFA-2LFA-3 receptorErythrocyte receptorRosette receptor
02
Mechanism of action
Modulation of immune responses (e.g., reducing overactive responses or inducing hyporesponsiveness)
03
Biological functions
Cell-cell adhesionCo-stimulationT-cell receptor (TCR) signaling modulationImmune cell activation
04
Disease associations
LymphomaLeukemiaImmune disordersViral evasion
05
Safety considerations
Potential for modulating immune responses (inducing hypo- or hyper-responsiveness)Pathogen evasion strategies targeting CD2/LFA-3 interaction
06
Interacting drugs
Anti-CD2 monoclonal antibodies
07
Biomarkers
Expression on T cells and NK cells (diagnostic marker)Pan-T phenotype in lymphomas/leukemias
Beyond the preview
Go deeper on T-cell Surface Antigen CD2 (CD2).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on T-cell Surface Antigen CD2 (CD2).