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Target intelligence / Profile preview
T-cell Surface Antigen CD3 (CD3)
- Target
- CD3
- Molecular classification
- Receptor, Co-receptor, Multimeric protein complex
01
Overview
CD3 is a multimeric protein complex associated with the T cell receptor (TCR) on T lymphocytes. It is essential for TCR assembly, surface expression, and signal transduction following antigen recognition. The complex consists of CD3εγ, CD3εδ, and CD3ζζ dimers. Upon antigen binding to the TCR, ITAM motifs within the CD3 cytoplasmic tails are phosphorylated, initiating downstream signaling cascades that lead to T cell activation. CD3 is expressed on all mature T cells and is used as a marker for identifying and quantifying T cells. Anti-CD3 antibodies are used therapeutically to modulate immune responses, such as in transplant rejection.
- Other names
- Cluster of Differentiation 3T3
02
Mechanism of action
CD3 modulation, T cell depletion/tolerization
03
Biological functions
Signal transductionT cell activationAntigen recognitionImmune responseT cell development
04
Disease associations
Transplant rejectionAutoimmunityCancer (lymphoma)Inflammation
05
Safety considerations
Cytokine release syndromeImmunosuppressionOpportunistic infections
06
Interacting drugs
OKT3
07
Biomarkers
CD3 expression levels for T cell countCD3 expression in lymphomas
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