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Target intelligence / Profile preview
T cell surface antigen CD4 (CD4)
- Target
- CD4
- Molecular classification
- Receptor, Type I transmembrane glycoprotein
01
Overview
CD4 is a type I transmembrane glycoprotein primarily expressed on helper T cells, monocytes, macrophages, and dendritic cells. It functions as a co-receptor for the T cell receptor (TCR) during antigen recognition, binding to MHC class II molecules and initiating downstream signaling cascades that lead to T cell activation and differentiation. It is a key therapeutic target for HIV/AIDS and is implicated in various autoimmune diseases and cancers.
- Other names
- T-cell surface glycoprotein CD4Cluster determinant 4Leu-3T-cell surface antigen T-helper-inducer marker
02
Mechanism of action
Co-receptor for TCR-MHC II interaction, amplifying downstream signaling through phosphorylation events.
03
Biological functions
Immune responseAntigen recognitionT cell activationSignal transductionT cell differentiationCo-receptor activity
04
Disease associations
HIV/AIDSCancerAutoimmune diseasesVitiligoType I diabetes mellitus
05
Safety considerations
CD4 depletion (HIV)Immune suppressionCytokine release syndrome (with antibody therapies)
06
Interacting drugs
HIV drugs (targeting CD4+ cells)
1 more in the full profile.
07
Biomarkers
CD4+ T cell count (HIV)CD4 expression in lymphomasCD4 expression in autoimmune diseases
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