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Target intelligence / Profile preview
T-cell surface glycoprotein CD3 (CD3)
- Target
- CD3
- Molecular classification
- Receptor, T cell receptor complex, Surface glycoprotein
01
Overview
CD3 is a multimeric protein complex found on the surface of T lymphocytes and is a defining marker of the T cell lineage. It functions as an essential co-receptor for the T cell receptor (TCR), playing a critical role in antigen recognition and signal transduction during adaptive immune responses.
- Other names
- Cluster of Differentiation 3
02
Mechanism of action
Modulation of immune responses by activating or tolerizing mature cells or inducing regulatory populations.
03
Biological functions
Signal transductionImmune responseT cell activationT cell proliferationT cell differentiation
04
Disease associations
Autoimmune diseasesImmunodeficiencyCancerInflammation
05
Safety considerations
Cytokine release syndromeImmunosuppression
06
Interacting drugs
Anti-CD3 antibodies
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