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Target intelligence / Profile preview
T cell surface glycoprotein CD3 complex (CD3)
- Target
- CD3
- Molecular classification
- Receptor complex, T cell receptor complex component
01
Overview
The CD3 complex is a multi-subunit protein complex on T lymphocytes, crucial for T cell development, antigen recognition, and signal transduction. It consists of CD3E, CD3G, CD3D, and CD3Z subunits forming heterodimers (CD3δε, CD3γε) and homodimer (CD3ζζ), associated with the TCR αβ or γδ heterodimers. ITAMs in the cytoplasmic domains initiate signaling upon antigen recognition. Defects can cause severe combined immunodeficiency and autoimmunity.
- Other names
- T-cell receptor-CD3 complexCD3 complex
02
Mechanism of action
Antibodies targeting CD3 can deplete T cells or modulate T cell activity. Small molecules can inhibit signaling pathways downstream of CD3 activation.
03
Biological functions
Signal transductionT cell activationAntigen recognitionT cell developmentReceptor assemblyImmune response
04
Disease associations
ImmunodeficiencyAutoimmunityType 1 diabetes
05
Safety considerations
Cytokine release syndromeImmunosuppressionIncreased risk of infection
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