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Target intelligence / Profile preview
T-cell surface glycoprotein CD3 epsilon chain (None)
- Target
- None
- Molecular classification
- Receptor, Immunoglobulin superfamily
01
Overview
The T-cell surface glycoprotein CD3 epsilon chain (CD3E) is an essential component of the T cell receptor (TCR)-CD3 complex found on the surface of T lymphocytes. Its primary role is to couple antigen recognition by the TCR to intracellular signal transduction pathways that activate immune responses. CD3E also plays a crucial role in proper development and maturation of functional T cells within the thymus. Mutations or defects in CD3E cause severe combined immunodeficiency (SCID). Variants have also been associated with increased susceptibility to autoimmune diseases such as type I diabetes mellitus.
02
Mechanism of action
Modulation of T-cell activation
03
Biological functions
Signal transductionAdaptive immunityT cell developmentRegulation of receptor densityImmune response
04
Disease associations
ImmunodeficiencyAutoimmune diseaseType I diabetes
05
Safety considerations
ImmunosuppressionIncreased risk of infection
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