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Target intelligence / Profile preview
T-cell surface glycoprotein CD5 (CD5)
- Target
- CD5
- Molecular classification
- Type I transmembrane glycoprotein, Scavenger receptor cysteine-rich (SRCR) superfamily member
01
Overview
CD5 is a 67 kDa type I transmembrane glycoprotein and a member of the scavenger receptor cysteine-rich (SRCR) superfamily. It is constitutively expressed on all mature T cells and thymocyte precursors and also on the B-1a subset in mice and some regulatory/anergic human/mouse B-cells. CD5 acts primarily as a negative regulator of antigen receptor signaling, inhibiting T-cell receptor (TCR) and B cell receptor (BCR) signaling and promoting T cell nonresponsiveness and survival. Modulation of CD5 within the tumor microenvironment corresponds to a strategy adopted by tumor-specific cytotoxic T lymphocytes to optimize their cytotoxic and cytokine secretion functions.
- Other names
- Leu-1Ly-1T1
02
Mechanism of action
Modulation of T cell receptor (TCR) and B cell receptor (BCR) signaling
03
Biological functions
Negative regulation of antigen receptor signaling (TCR/BCR)T cell toleranceB cell toleranceModulation of antitumor immune responses
04
Disease associations
CancerAutoimmunity
05
Safety considerations
Potential for immune-related adverse events due to modulation of T cell and B cell function
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