Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
T-cell surface glycoprotein CD5 (CD5)
- Target
- CD5
- Molecular classification
- Type I transmembrane glycoprotein, Scavenger receptor cysteine-rich (SRCR) superfamily member
01
Overview
CD5 is a 67 kDa type I transmembrane glycoprotein and a member of the scavenger receptor cysteine-rich (SRCR) superfamily. It is constitutively expressed on all mature T cells and thymocyte precursors and also on the B-1a subset in mice and some regulatory/anergic human/mouse B-cells. CD5 acts primarily as a negative regulator of antigen receptor signaling, inhibiting T-cell receptor (TCR) and B cell receptor (BCR) signaling and promoting T cell nonresponsiveness and survival. Modulation of CD5 within the tumor microenvironment corresponds to a strategy adopted by tumor-specific cytotoxic T lymphocytes to optimize their cytotoxic and cytokine secretion functions.
- Other names
- Leu-1Ly-1T1
02
Mechanism of action
Modulation of T cell receptor (TCR) and B cell receptor (BCR) signaling
03
Biological functions
Negative regulation of antigen receptor signaling (TCR/BCR)T cell toleranceB cell toleranceModulation of antitumor immune responses
04
Disease associations
CancerAutoimmunity
05
Safety considerations
Potential for immune-related adverse events due to modulation of T cell and B cell function
Beyond the preview
Go deeper on T-cell surface glycoprotein CD5 (CD5).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on T-cell surface glycoprotein CD5 (CD5).