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Target intelligence / Profile preview
T helper 17 cell pathway (Th17 pathway)
- Target
- Th17 pathway
- Molecular classification
- Cytokine pathway, Transcription factor network, Immune signaling pathway
01
Overview
The T helper 17 (Th17) cell pathway is a critical component of the adaptive immune system, playing a role in host defense and tissue inflammation. Th17 cells are characterized by the production of IL-17 family cytokines and their involvement in autoimmune and inflammatory diseases. Inhibition of the Th17 cell pathway aims to suppress the differentiation, function, or survival of these cells, often targeting key cytokines (IL-6, TGFβ), transcription factors (RORγt), or effector cytokines (IL-17A).
- Other names
- T helper 17 cellsTh17IL-17 pathway
02
Mechanism of action
Inhibition of Th17 cell differentiation, function, or survival through targeting of key signaling molecules, transcription factors, or effector cytokines.
03
Biological functions
Immune responseInflammationHost defenseT cell differentiationCytokine production
04
Disease associations
Autoimmune diseasesChronic inflammatory conditionsInfectionPsoriasisRheumatoid arthritisMultiple sclerosisInflammatory bowel disease
05
Safety considerations
Increased risk of infectionImmunosuppressionPotential for off-target effectsExacerbation of pre-existing conditions
06
Interacting drugs
Ustekinumab
5 more in the full profile.
07
Biomarkers
IL-17AIL-17FIL-21IL-22
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