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Target intelligence / Profile preview
T Helper 2 Cell Activity (Th2 Activity)
- Target
- Th2 Activity
- Molecular classification
- Cellular Activity, Immune Response
01
Overview
Th2 cell activity refers to the functional actions of T helper 2 (Th2) cells, a specialized subset of CD4+ T lymphocytes. Th2 cells are central mediators of the humoral (antibody-mediated) immune response, particularly against extracellular parasites such as helminths, and play a pivotal role in allergic reactions and tissue repair. They orchestrate immune responses by secreting characteristic cytokines including IL-4, IL-5, IL-6, IL-9, IL-10, IL-13, and IL-25, which stimulate B cell class-switching to IgE, activate eosinophils and basophils, promote mast cell hyperplasia, and induce mucus production.
- Other names
- Th2 Cell FunctionType 2 T Helper Cell ActivityTh2 Response
02
Biological functions
Humoral ImmunityAllergy MediationTissue RepairCytokine Production (IL-4, IL-5, IL-6, IL-9, IL-10, IL-13, IL-25)
03
Disease associations
Allergic Diseases (Asthma, Atopic Dermatitis, Allergic Rhinitis)Autoimmune Conditions (Chronic Graft-versus-Host Disease, Systemic Sclerosis/Lupus Erythematosus)Inflammation
04
Safety considerations
Potential for exacerbation of allergic reactionsRisk of immune dysregulation
05
Biomarkers
Elevated IL-4, IL-5, IL-13 levels in serum or tissueIncreased IgE levelsEosinophilia
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