T-helper cell type 2 lymphocyte (Th2 cell)

T-helper cell type 2 (Th2) lymphocytes are a CD4+ T cell subset central to humoral immune responses by producing cytokines (IL-4, IL-5, IL-13, etc.) that stimulate B cells, drive IgE production, and recruit eosinophils/basophils, playing a major role in protection against extracellular parasites and in the pathology of allergic conditions and asthma. Th2 cell activity is regulated by signals such as IL-4 and transcription factors like GATA3 and STAT6. Dysregulation can lead to allergies, autoimmune diseases, and impaired defense against certain pathogens

Other names

Type 2 helper T cellTh2 lymphocyteCD4+ Th2 cell

Cytokine inhibition (blockade of IL-4, IL-5, IL-13, TSLP, etc.) reduces Th2-driven inflammation; Inhibition of Th2 cell differentiation or function via blocking transcription factors such as GATA3, STAT6; JAK/STAT pathway blockade downstream of Th2-promoting cytokine receptors