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Target intelligence / Profile preview
T Helper Cell Type 2 Pathway (Th2 Pathway)
- Target
- Th2 Pathway
- Molecular classification
- Signaling Pathway, Immune Pathway
01
Overview
The T helper cell type 2 (Th2) pathway orchestrates humoral immune responses, particularly against extracellular parasites, bacteria, allergens, and toxins. It involves the differentiation and function of Th2 cells, which produce cytokines that drive B cell activation, antibody class switching (especially to IgE), and recruitment of eosinophils and basophils. Overactivation or dysregulation of the Th2 pathway is implicated in allergic diseases and certain autoimmune conditions.
- Other names
- Th2 Immune ResponseType 2 Helper T Cell Pathway
02
Biological functions
Humoral ImmunityB Cell ActivationAntibody Production (IgE)Eosinophil RecruitmentBasophil RecruitmentMucus ProductionAirway Hyper-responsivenessImmune RegulationTissue Repair
03
Disease associations
Allergic Diseases (Asthma, Atopic Dermatitis)Hypersensitivity ReactionsAutoimmune Diseases (Systemic Lupus Erythematosus)Chronic Graft-versus-Host DiseaseExtracellular Parasite Infections
04
Safety considerations
Excessive Th2 responses can exacerbate allergic and autoimmune conditions.
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