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Target intelligence / Profile preview
T-lymphocyte activation antigen CD80 (CD80)
- Target
- CD80
- Molecular classification
- Immunoglobulin superfamily, B7 family, Receptor
01
Overview
T-lymphocyte activation antigen CD80 (B7-1) is a costimulatory molecule crucial for regulating T-cell activation and immune responses. Expressed on antigen-presenting cells (APCs), it binds to CD28 (stimulatory) and CTLA-4 (inhibitory) receptors on T-cells, modulating their activity. CD80 plays a role in both innate and adaptive immunity and is implicated in cancer and autoimmune diseases, making it a target for therapeutic interventions.
- Other names
- B7-1BB1CTLA-4 counter-receptor B7.1Activation B7-1 antigen
02
Mechanism of action
Blocks interaction between CD28/CTLA4 and CD80, preventing T-cell costimulation or inhibition
03
Biological functions
T-cell costimulationT-cell inhibitionImmune response regulationAntigen presentationB-cell activationInnate ImmunityAdaptive Immunity
04
Disease associations
CancerAutoimmune diseasesMultiple sclerosisSystemic lupus erythematosus (SLE)Glomerular diseasesMinimal change nephropathy
05
Safety considerations
Immune-related adverse events associated with immunomodulatory therapiesPotential for off-target effects
06
Interacting drugs
Abatacept
07
Biomarkers
CD80+ lymphocytes in circulation or tissue (potential indicator for treatment efficacy or disease progression)
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