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Target intelligence / Profile preview
T lymphocyte activation via costimulatory molecule signaling
- Molecular classification
- Other
01
Overview
T lymphocyte activation via costimulatory molecule signaling is the process by which T cells require a secondary, antigen-independent signal, in addition to T cell receptor (TCR) engagement, to enable full activation, proliferation, and effector function[3][5]. These costimulatory signals are mediated by various receptor-ligand pairs, notably CD28 binding to B7 molecules (CD80/CD86) on antigen-presenting cells, among many other pairs such as ICOS/ICOS-L, 4-1BB/4-1BBL, and OX40/OX40L[1][3][5]. This process is critical for proper immune responses, prevention of autoimmunity, and is a central focus in immunotherapy for cancer, autoimmunity, and transplant rejection[1][4][5].
- Other names
- Costimulatory signaling in T cellsT cell costimulationT cell secondary signaling
02
Biological functions
Immune responseSignal transductionCell proliferationImmune toleranceOther
03
Disease associations
CancerInflammationAutoimmune diseaseInfectionGraft rejection
04
Safety considerations
Immune-related adverse events (with inappropriate or excessive activation/suppression)AutoimmunityCytokine release syndrome
05
Biomarkers
CD28, CTLA-4, PD-1, ICOS, OX40, 4-1BB expression (when referenced in clinical immune-oncology assays)
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