T lymphocyte and B lymphocyte (T cell and B cell)

T lymphocyte and B lymphocyte are two distinct subtypes of lymphocytes, a major class of white blood cells fundamental to the adaptive immune system[3][4][5][7][8]. - **T lymphocytes** are primarily responsible for cell-mediated immunity, recognizing and destroying infected or abnormal cells and orchestrating immune responses via cytokine release and helper functions[6][7]. - **B lymphocytes** mediate humoral immunity through production and secretion of antibodies, serving as precursors to plasma cells and memory B cells[1][8]. Both cell types express specific antigen receptors (TCR for T cells, BCR for B cells), are central to immune memory, and participate in nearly all aspects of adaptive immune defense, as well as many immune-mediated diseases[2][3][4][5][6][7][8]. Dysfunction or therapeutic modulation of these cells underlies numerous infectious, malignant, and immune-mediated conditions. Note: If you are seeking information about a specific therapeutic target, such as "CD20" (on B cells) or "PD-1" (on T cells), it is preferable to specify the precise molecule or receptor rather than the entire cell type. The entry "T lymphocytes and B lymphocytes" is not a standard pharmacological or molecular target, but classes of immune cells with diverse roles and many interacting surface molecules[3][4][8].

Other names

T cellB cellT lymphocyteB lymphocyteT helper cellCytotoxic T cellPlasma cellMemory B cell

Modulation or depletion of cell population (e.g., anti-CD20 monoclonal antibodies deplete B cells) Activation/inhibition of receptors (e.g., PD-1/PD-L1 blockade reactivates T cells) Immune suppression (e.g., calcineurin inhibitors suppress T cell activation) Adoptive cell transfer (infusion of engineered T cells)