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Target intelligence / Profile preview
T lymphocyte immunoglobulin mucin-domain containing-protein-3 (TIM-3)
- Target
- TIM-3
- Molecular classification
- Type I transmembrane protein, Immunoregulatory protein, Receptor
01
Overview
TIM-3 is a type I transmembrane protein and a member of the TIM family of immunoregulatory proteins. It is expressed on various immune cells, including T cells, NK cells, dendritic cells, and macrophages. TIM-3 functions as an immune checkpoint receptor with both inhibitory and activating roles, depending on the cellular context and ligand engagement. It is implicated in autoimmunity, cancer, and chronic infections, and is being explored as a therapeutic target for cancer immunotherapy.
- Other names
- T-cell immunoglobulin and mucin-domain containing-3CD366HAVCR2
02
Mechanism of action
Inhibition of T cell activation and effector function; enhancement of NK cell activity; modulation of myeloid cell function.
03
Biological functions
Immune regulationT cell inhibitionT cell activation (context-dependent)Tolerance inductionCytokine production regulationNK cell activation (context-dependent)
04
Disease associations
AutoimmunityCancerChronic infection
05
Safety considerations
Potential exacerbation of autoimmune reactionsContext-dependent effects on immune activation/suppression
06
Interacting drugs
Monoclonal antibodies targeting TIM-3
1 more in the full profile.
07
Biomarkers
TIM-3 expression levels on tumor-infiltrating lymphocytesPolymorphisms associated with susceptibility to autoimmune/allergic diseases
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