T Lymphocyte Replacements

T lymphocyte replacements encompass therapeutic strategies involving the substitution, modification, or engineering of T cells to restore or enhance immune function. These approaches, including adoptive cell therapy, CAR-T cell therapy, and orthotopic TCR replacement, are primarily used in immunotherapy for cancer and other diseases where the immune system is compromised or needs redirection. They involve collecting, modifying (often genetically), expanding, and re-infusing T cells to target specific diseases.

Other names

Adoptive cell therapyAdoptive immunotherapyImmune cell therapyCellular immunotherapy

T lymphocytes are engineered or selected to recognize and eliminate specific target cells (e.g., cancer cells) or to modulate the immune response.