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Target intelligence / Profile preview
T Lymphocyte Surface Antigen CD2 (CD2)
- Target
- CD2
- Molecular classification
- Transmembrane glycoprotein, Immunoglobulin superfamily member, Cell adhesion molecule
01
Overview
CD2 is a transmembrane glycoprotein and cell adhesion molecule primarily expressed on T cells and NK cells. It plays critical roles in cell adhesion and signal transduction during immune responses, acting as a co-stimulatory molecule. CD2 interacts with LFA-3/CD58 or CD48, facilitating stable contact during immune synapse formation. Monoclonal antibodies targeting CD2 have been developed for modulating undesired immune responses such as autoimmune diseases or transplant rejection.
- Other names
- T11LFA-2Erythrocyte rosette receptorLFA-3 receptor
02
Mechanism of action
Monoclonal antibodies targeting CD2 modulate immune responses by blocking adhesion and/or signaling.
03
Biological functions
Cell adhesionCo-stimulationSignal transductionImmunological synapse formation
04
Disease associations
Autoimmune diseasesTransplant rejectionLeukemiasLymphomasInflammation
05
Safety considerations
Potential for immunosuppressionRisk of infectionsPotential for cytokine release syndrome
06
Interacting drugs
Alefacept
1 more in the full profile.
07
Biomarkers
CD2 expression level on T cells and NK cells (diagnostic and potentially predictive)
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