Target intelligence / Profile preview

T lymphocyte surface antigen CD3 (CD3)

Target: CD3
Molecular classification: Receptor, Multi-subunit receptor complex, Transmembrane protein

Overview

CD3 is a multi-subunit protein complex and a defining marker of T cells. It functions as a co-receptor that associates noncovalently with the T cell receptor (TCR) and is essential for antigen recognition and signal transduction during immune responses. The CD3 complex consists of gamma (γ), delta (δ), epsilon (ε), and zeta (ζ) chains, each containing ITAMs in their cytoplasmic domains that initiate downstream signaling cascades upon TCR engagement.

Other names: Cluster of Differentiation 3CD3 antigen

Mechanism of action

Modulation or depletion of T cell populations via antibody-mediated effects; receptor agonism to modulate T cell activity

Biological functions

Antigen recognitionSignal transductionT cell activationImmune responseT cell development

Disease associations

Autoimmune diseasesCancerImmunodeficiencyInflammationGraft-versus-host disease

Safety considerations

Cytokine release syndromeImmunosuppressionOpportunistic infectionsHypersensitivity reactions

Interacting drugs

Muromonab-CD3 (Orthoclone OKT3)

2 more in the full profile.

Biomarkers

CD3 expression levels as a marker of T cell presence and activationT cell receptor occupancy by therapeutic antibodies

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