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Target intelligence / Profile preview
T lymphocyte surface antigen CD52 (CD52)
- Target
- CD52
- Molecular classification
- Glycoprotein, Cell surface antigen
01
Overview
CD52 is a small, highly glycosylated protein expressed on mature lymphocytes and other immune cells. It is anchored to the cell membrane via a GPI linkage. While its precise function is incompletely understood, it plays a role in immune regulation, including T-cell activation suppression and complement system modulation. Alemtuzumab, a monoclonal antibody targeting CD52, is used to deplete lymphocytes in the treatment of certain leukemias/lymphomas and multiple sclerosis.
- Other names
- CAMPATH-1 antigenCluster of differentiation 52CDW52EDDM5HE5
02
Mechanism of action
Targeted depletion of CD52-expressing cells through complement-mediated lysis or antibody-dependent cellular cytotoxicity.
03
Biological functions
Immune response regulationT-cell activation suppressionB-cell signaling inhibitionComplement system modulationApoptosis induction
04
Disease associations
Listeria meningitisLymphoproliferative syndromesMultiple sclerosisAutoimmune diseases
05
Safety considerations
ImmunosuppressionIncreased risk of infections
06
Interacting drugs
Alemtuzumab
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