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Target intelligence / Profile preview
T Lymphocyte Surface Antigen CD8
- Molecular classification
- Receptor, Transmembrane protein, Type I membrane protein
01
Overview
The surface antigen CD8 is critical for enabling cytotoxic function in specific subsets of lymphocytes. It acts both structurally—by stabilizing interactions with MHC class I—and functionally—by facilitating targeted destruction of abnormal or infected host cells. Its presence defines one major lineage within adaptive immunity essential for pathogen clearance and tumor control
- Other names
- CD8Cytotoxic/Suppressor-T Lymphocyte Antigen
02
Mechanism of action
N/A
03
Biological functions
Antigen recognitionCytolysisImmune responseCytokine productionCell-mediated immunityT cell activation
04
Disease associations
Viral infectionsCancerAutoimmune diseasesImmunodeficiency
05
Safety considerations
Cytokine release syndromeOff-target effects on other immune cellsAutoimmunity
06
Biomarkers
CD8+ T cell count in bloodCD8 expression levels in tumors
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