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Target intelligence / Profile preview
T-type Calcium Channel Cav3 (Cav3)
- Target
- Cav3
- Molecular classification
- Ion channel, Voltage-gated calcium channel
01
Overview
T-type calcium channels (Cav3) are a subfamily of voltage-gated calcium channels characterized by their low threshold for activation and rapid inactivation. They play crucial roles in regulating electrical excitability and rhythmic firing in various cell types, including neurons and cardiac muscle cells. The family consists of three main isoforms: Cav3.1 (CACNA1G), Cav3.2 (CACNA1H), and Cav3.3 (CACNA1I). Dysfunction or mutations are linked with absence epilepsy, neuropathic pain and idiopathic epilepsy. They are targets for drug development especially for neurological disorders.
- Other names
- T-type calcium channelsCACNA1G (Cav3.1)CACNA1H (Cav3.2)CACNA1I (Cav3.3)
02
Mechanism of action
Blockage or modulation of calcium ion flow through the channel
03
Biological functions
PacemakingNeuronal firingRegulation of neuronal excitabilitySubthreshold processing
04
Disease associations
Epilepsy (absence/idiopathic)Neuropathic pain
05
Safety considerations
Potential for off-target effects due to structural similarity with other calcium channelsSubtype-specific selectivity challenges
06
Interacting drugs
Ni²⁺
1 more in the full profile.
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