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Target intelligence / Profile preview
T-type Calcium Channel Protein (Cav3.x)
- Target
- Cav3.x
- Molecular classification
- Ion channel, Voltage-gated calcium channel
01
Overview
T-type calcium channels (Cav3.x) are a family of low voltage-activated, voltage-gated calcium channels. They are characterized by their ability to open at relatively negative membrane potentials, rapid activation and inactivation kinetics, and small single-channel conductance. They play critical roles in pacemaking activity, neuronal excitability, smooth muscle contraction, and hormone secretion. Alterations in T-type channel function have been linked to epilepsy and neuropathic pain, making them therapeutic targets.
- Other names
- Low voltage-activated calcium channelsCACNA1GCACNA1HCACNA1Iα1G subunitα1H subunitα1I subunit
02
Mechanism of action
T-type calcium channel blockade
03
Biological functions
Pacemaking activityRegulation of neuronal excitabilitySynaptic transmissionSmooth muscle contractionHormone secretionSensory processingCardiac rhythm control
04
Disease associations
EpilepsyNeuropathic pain
05
Safety considerations
Potential for off-target effects due to structural similarity with other ion channelsCardiovascular effectsNeurological effects
06
Interacting drugs
Ni²⁺
4 more in the full profile.
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