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Target intelligence / Profile preview
T-type calcium channel protein subunit alpha1G (CACNA1G)
- Target
- CACNA1G
- Molecular classification
- Ion channel, Voltage-gated calcium channel, T-type calcium channel
01
Overview
CACNA1G encodes the α1G subunit of the low-voltage activated (LVA), or "T-type," calcium channels. These channels are crucial for regulating intracellular processes such as contraction, secretion, neurotransmission, and gene expression. It is especially important in Thalamocortical relay neurons and Pacemaking activity. Mutations affecting this protein can alter its electrophysiological properties which may result in neurological phenotypes.
- Other names
- Ca_v3.1calcium channel, voltage-dependent, T type, alpha 1G subunit
02
Mechanism of action
Inhibition of T-type calcium channels, reducing calcium influx and neuronal excitability.
03
Biological functions
Regulation of intracellular calcium levelsNeuronal excitabilityPacemaking activityNeurotransmissionGene expressionContractionSecretion
04
Disease associations
Absence epilepsyCardiac arrhythmiasPainParkinson’s diseaseCancer
05
Safety considerations
Side effects associated with calcium channel blockersPotential for drug interactions
06
Interacting drugs
Ethosuximide
1 more in the full profile.
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