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Target intelligence / Profile preview
T-type Calcium Channel Subunit Alpha1G (CACNA1G)
- Target
- CACNA1G
- Molecular classification
- Ion channel, Voltage-gated calcium channel, T-type calcium channel
01
Overview
The T-type calcium channel subunit alpha1G is the pore-forming component of the voltage-dependent T-type (transient, low-voltage activated) calcium channels. These channels are crucial for mediating calcium ion entry into excitable cells and play key roles in various physiological processes, including pacemaking activity in neurons and cardiac nodal cells, hormone or neurotransmitter release, gene expression regulation, cell motility, division, and death. They are targets for research into epilepsy, pain management, cardiovascular diseases like arrhythmias/hypertension, sleep disorders etc.
- Other names
- Alpha-1G subunitCav3.1Voltage-dependent T-type calcium channel subunit alpha-1G
02
Mechanism of action
Inhibition of T-type calcium currents
03
Biological functions
Low voltage-gated calcium channel activityAxon guidanceCalcium ion import across plasma membraneMembrane depolarization during action potential generation/conductionPositive regulation of exocytosis dependent on Ca²⁺Regulation of atrial cardiac muscle cell depolarization & heart rateSynaptic transmission modulationPacemaker activityRegulation of neuronal firing patterns
04
Disease associations
EpilepsyPainCardiovascular diseases (arrhythmias, hypertension)Sleep disorders
05
Safety considerations
Potential for off-target effects due to widespread expressionCardiac effects due to role in pacemaking
06
Interacting drugs
Mibefradil
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