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Target intelligence / Profile preview
T-type Voltage-Dependent Calcium Channel
- Molecular classification
- Voltage-gated Calcium Channel, Ion Channel, Ca_v3 subfamily
01
Overview
T-type voltage-dependent calcium channels are a class of low-voltage activated (LVA) calcium channels that open in response to small depolarizations of the cell membrane. They are called "T-type" due to their transient current profile—activating and inactivating rapidly. They play critical roles in pacemaking activity, calcium signaling, and neuronal firing modulation and are implicated in various pathologies including epilepsy, cardiac arrhythmias, hypertension, and neuropathic pain.
- Other names
- Ca_v3.xCav3.1Cav3.2Cav3.3α1Gα1Hα1I
02
Mechanism of action
T-type calcium channel blockade
03
Biological functions
Pacemaking activityModulation of neuronal firingHormone releaseNeurotransmitter releaseCalcium signalingRegulation of gene expressionMuscle contraction/relaxationCell motilityCell divisionCell death
04
Disease associations
EpilepsyCardiac arrhythmiasHypertensionNeuropathic painEndocrine disorders
05
Safety considerations
Potential for cardiac side effectsNeurological side effects
06
Interacting drugs
Nickel ions
4 more in the full profile.
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