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T-type Voltage-Gated Calcium Channel
- Molecular classification
- Ion channel, Voltage-gated calcium channel, CaV3 subfamily
01
Overview
T-type voltage-gated calcium channels are a class of low-voltage-activated (LVA) ion channels that permit the influx of calcium ions (Ca²⁺) into excitable and some non-excitable cells in response to small depolarizations of the cell membrane. The "T" stands for "transient," reflecting their rapid activation and inactivation kinetics. There are three main isoforms: CaV3.1 (CACNA1G), CaV3.2 (CACNA1H), and CaV3.3 (CACNA1I). They play crucial roles in pacemaking, neuronal excitability, hormone secretion, and smooth muscle contraction. Dysfunction is implicated in epilepsy, neuropathic pain, cardiac arrhythmias, and hypertension. Mibefradil and Ni²⁺ are known blockers.
02
Mechanism of action
T-type calcium channel blockade
03
Biological functions
PacemakingNeuronal excitabilityHormone secretionSmooth muscle contractionRegulation of vascular tone
04
Disease associations
EpilepsyNeuropathic painCardiac arrhythmiasHypertension
05
Interacting drugs
Mibefradil
1 more in the full profile.
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