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Target intelligence / Profile preview
T-type voltage-gated calcium channel 3.1 (Cav3.1)
- Target
- Cav3.1
- Molecular classification
- Ion channel, Voltage-gated calcium channel, T-type calcium channel
01
Overview
Cav3.1 is a low-voltage activated calcium channel essential for regulating electrical excitability across several organ systems—including brain circuits underlying cognition/memory formation, immune cell signaling, cardiac rhythm generation, vascular tone, and more—making it an attractive target for therapeutic intervention across neurological, cardiovascular, renal, immunological disorders.
- Other names
- CACNA1Gα1G subunit
02
Mechanism of action
T-type channel antagonists could modulate excessive excitability or abnormal rhythmic activity.
03
Biological functions
Pacemaking activityModulation of neuronal excitabilitySynaptic plasticityRegulation of vascular toneImmune cell activation
04
Disease associations
Autoimmune diseasesCognitive dysfunctionEpilepsyNeuropathic painCardiac arrhythmiasHypertension
05
Interacting drugs
T-type channel blockers
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