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Target intelligence / Profile preview
T-type voltage-gated calcium channel 3.2 (Cav3.2)
- Target
- Cav3.2
- Molecular classification
- Voltage-gated calcium channel, CaV3 subfamily, Ion channel
01
Overview
Cav3.2 is a subtype of T-type voltage-gated calcium channels, encoded by the CACNA1H gene. It is widely expressed throughout the central nervous system and peripheral tissues, playing critical roles in neuronal excitability, pacemaking activity, and pain signaling. Dysfunction or altered expression/activity of Cav3.2 has been linked to several disorders, including neuropathic pain and absence epilepsy, making it a promising target for analgesics development.
02
Mechanism of action
Selective antagonists block ion flow via distinct structural mechanisms
03
Biological functions
Neuronal excitabilityRhythmic firing/pacemakingNociceptionRegulation of pacemaker activityModulating neurotransmitter releaseSynaptic plasticityMediating rapid Ca2+ influx
04
Disease associations
Neuropathic painAbsence epilepsyOther Neurological Disorders
05
Interacting drugs
ACT-709478
3 more in the full profile.
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