TACR3 antisense RNA 1 (TACR3-AS1)

TACR3 antisense RNA 1 is a long non-coding RNA gene located on chromosome 4 (coordinates: 103,548,745–103,624,534, forward strand) and is transcribed antisense to the TACR3 gene (which encodes the neurokinin-3 receptor)[3]. TACR3-AS1 shares several aliases, notably RP11-297P16.3. Antisense lncRNAs such as TACR3-AS1 are often involved in regulating the expression of their sense counterparts by transcriptional interference, chromatin modification, or RNA-RNA interactions[2][8]. While little is specifically published on the molecular function of TACR3-AS1, similar antisense RNAs are crucial regulators of gene expression and may play roles in disease by affecting the epigenetic landscape or mRNA stability of adjacent genes[2]. Notably, research indicates knockdown of TACR3-AS1 inhibits migration and invasion of laryngeal squamous carcinoma cells, suggesting a potential role in cancer biology, though no drugs or clinical biomarkers are associated with this lncRNA[11]. If structured information is needed for other genes such as TACR3 (which is a G protein-coupled receptor implicated in signal transduction and targeted in various diseases), please specify. TACR3-AS1 remains a research subject for its potential regulatory and disease roles but is neither a direct therapeutic target nor a clinical biomarker.

Other names

RP11-297P16.3TACR3-AS1

Not applicable; as a regulatory lncRNA, it is not directly targeted by drugs. However, antisense oligonucleotide technologies theoretically could modulate its activity—general mechanisms include hybridization-dependent knockdown via RNase H, altered splicing, or regulation of translation