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Target intelligence / Profile preview
Family with Sequence Similarity 19 Member A5 (FAM19A5)
- Target
- FAM19A5
- Molecular classification
- Secreted protein, Chemokine-like protein
01
Overview
Family with Sequence Similarity 19 Member A5 (FAM19A5), also known as TAFA5, is a secreted chemokine-like protein highly expressed in the brain and adipose tissue. It acts as a regulator of cell proliferation and migration via G protein-coupled receptors, particularly S1PR2 and FPR2. FAM19A5 plays a protective role in the cardiovascular system by inhibiting vascular smooth muscle cell activation and neointima formation. In the nervous system, it promotes neuronal differentiation and is implicated in neurological diseases like Alzheimer's disease. Lower serum levels are observed in obese individuals, suggesting its potential as a biomarker for metabolic disorders and cardiovascular risk.
- Other names
- TAFA chemokine like family member 5TAFA5Chemokine-like protein TAFA-5QLLK5208UNQ5208
02
Mechanism of action
Acts as a chemokine-like protein regulating cell proliferation and migration via G protein-coupled receptors (GPCRs), notably S1PR2 and FPR2.
03
Biological functions
Regulation of cell proliferationRegulation of cell migrationInhibition of vascular smooth muscle cell (VSMC) proliferation/migrationSuppression of neointima formationStimulation of macrophage migrationInhibition of osteoclast formation
04
Disease associations
ObesityMetabolic disordersCardiovascular diseaseNeurological diseasesAlzheimer's disease
05
Biomarkers
Serum levels in obese childrenCorrelation with BMI and fasting insulin
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