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TAGAP antisense RNA 1 (TAGAP-AS1)

Target
TAGAP-AS1
Molecular classification
Long non-coding RNA (lncRNA), Antisense RNA
01

Overview

TAGAP antisense RNA 1 (TAGAP-AS1) is a long non-coding RNA transcribed antisense to the TAGAP gene locus. Like other antisense lncRNAs, TAGAP-AS1 is thought to regulate gene expression potentially through modulation of its associated sense transcript (TAGAP mRNA), possibly impacting transcription, mRNA stability, or epigenetic state, following the general mechanisms described for antisense RNAs[1][3][4]. The precise functional and pathological roles of TAGAP-AS1 remain only partially characterized, though it has been associated with ciliary dyskinesia, primary, 32 in gene-disease association resources[5]. As with most lncRNAs, its mechanisms of action are complex and context-dependent, commonly in gene regulation but not as direct drug targets.

Other names
TAGAP-AS1
02

Biological functions

Regulation of gene expressionLikely cis- and trans-regulation of gene transcription (by modulating chromatin or transcript stability as is typical of antisense lncRNAs)
03

Disease associations

Ciliary dyskinesia, primary, 32

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