Talin-1 (TLN1)

Talin-1 is a high molecular weight cytoskeletal adaptor protein encoded by the TLN1 gene. It is ubiquitously expressed and localized to regions of cell–matrix and cell–cell contacts, especially at focal adhesions and costameres in muscle tissues. Talin-1 acts as a crucial mediator connecting integrins (especially β1 and β3 integrins) to the actin cytoskeleton, facilitating cell adhesion, migration, and activation of integrins[1][2][6]. Its structural domains enable binding to actin, integrins, vinculin, and other proteins involved in cytoskeletal organization. In various tissues, talin-1 is vital for maintaining cell structure and signaling. In mouse models, loss of talin-1 leads to defects in platelet aggregation, muscle integrity, and is embryonically lethal[1]. In humans, altered TLN1 expression is observed in certain disease states, such as increased expression in heart failure. No direct pharmacological modulators are approved clinically, but its functions connect it to roles in cardiovascular disease, myopathies, and immune-related hemostatic disorders[1][2][5][6].

Other names

Talin 1KIAA1027TLNILWEQtalin-1TLN1

Not applicable—no direct modulatory drugs are currently known. Modulation would theoretically involve interfering with integrin–cytoskeleton linkage or integrin activation.